Panthawi ya mliri, madotolo akugwiritsa ntchito ma antibodies opangidwa ndi labotale (ma antibodies opangidwa ndi labotale) kuthandiza odwala kulimbana ndi matenda a COVID-19. Tsopano ofufuza a UC Davis akuyesera kupanga ma antibodies a monoclonal omwe angathandize kulimbana ndi ululu wosatha. Cholinga chake ndi kupanga mankhwala osagwiritsa ntchito mankhwala osokoneza bongo pamwezi omwe angalowe m'malo mwa opioid.
Ntchitoyi imatsogoleredwa ndi Vladimir Yarov-Yarovoi ndi James Trimmer, aprofesa ku Dipatimenti ya Physiology ndi Biology ya Membrane ku yunivesite ya California, Davis School of Medicine. Iwo adasonkhanitsa gulu lamagulu ambiri lomwe linaphatikizapo ofufuza omwewo omwe anali kuyesa kutembenuza poizoni wa tarantula kukhala mankhwala opweteka.
Kumayambiriro kwa chaka chino, Yarov-Yarovoy ndi Trimmer adalandira thandizo la $ 1.5 miliyoni kuchokera ku pulogalamu ya National Institutes of Health's HEAL, yomwe ndi kuyesa mwamphamvu kufulumizitsa mayankho asayansi kuti akhale ndi vuto la opioid mdziko muno.
Chifukwa cha kupweteka kosatha, anthu amatha kutengera opioid. Centers for Disease Control's National Center for Health Statistics ikuyerekeza kuti pakhala anthu 107,622 omwe amwalira ndi mankhwala osokoneza bongo ku United States mu 2021, pafupifupi 15% kuposa omwe amwalira 93,655 mu 2020.
"Zomwe zachitika posachedwapa mu biology yopangidwa ndi makompyuta - kugwiritsa ntchito makompyuta kuti amvetsetse ndi kutsanzira machitidwe achilengedwe - akhazikitsa maziko ogwiritsira ntchito njira zatsopano zopangira ma antibodies monga mankhwala abwino kwambiri ochizira ululu wosatha," adatero Yarov. Yarovoy, wosewera wamkulu wa mphotho ya Sai.
"Ma antibodies a monoclonal ndiye malo omwe akukula mwachangu pamsika wamankhwala ndipo amapereka zabwino zambiri kuposa mankhwala ang'onoang'ono a molekyulu," adatero Trimmer. Mankhwala ang'onoang'ono a molekyulu ndi mankhwala omwe amalowa mosavuta m'maselo. Amagwiritsidwa ntchito kwambiri pazamankhwala.
Kwa zaka zambiri, labu ya Trimmer yapanga masauzande a ma antibodies osiyanasiyana a monoclonal pazifukwa zosiyanasiyana, koma uku ndiko kuyesa koyamba kupanga antibody yopangidwa kuti ichepetse ululu.
Ngakhale zikuwoneka zam'tsogolo, bungwe la US Food and Drug Administration lavomereza ma antibodies a monoclonal pofuna kuchiza ndi kupewa migraine. Mankhwala atsopanowa amagwira ntchito pa mapuloteni okhudzana ndi mutu waching'alang'ala wotchedwa calcitonin peptide yokhudzana ndi jini.
Pulojekiti ya UC Davis ili ndi cholinga chosiyana - njira za ion zapadera m'maselo a mitsempha yotchedwa voltage-gated sodium channels. Njira zimenezi zili ngati “mabowo” a m’maselo a minyewa.
“Ma cell a minyewa ndi amene ali ndi udindo wotumiza zizindikiro za ululu m’thupi. Njira zopangira ma ayoni a sodium m'maselo amitsempha ndizomwe zimapatsira ululu," akutero Yarov-Yarovoy. "Cholinga chathu ndikupanga ma antibodies omwe amalumikizana ndi malo opatsirana awa pamlingo wa maselo, kuletsa ntchito yawo ndikuletsa kutumiza kwazizindikiro zowawa."
Ofufuzawa adayang'ana njira zitatu za sodium zomwe zimagwirizanitsidwa ndi ululu: NaV1.7, NaV1.8, ndi NaV1.9.
Cholinga chawo ndikupanga ma antibodies omwe amafanana ndi njirazi, monga kiyi yomwe imatsegula loko. Njira yowunikirayi yapangidwa kuti iletse kufalikira kwa zizindikiro zowawa kudzera mumsewu popanda kusokoneza zizindikiro zina zomwe zimafalitsidwa kudzera m'maselo a mitsempha.
Vuto ndilakuti kapangidwe ka njira zitatu zomwe akuyesera kutsekereza ndizovuta kwambiri.
Kuti athetse vutoli, amatembenukira ku mapulogalamu a Rosetta ndi AlphaFold. Ndi Rosetta, ochita kafukufuku akupanga mitundu yovuta yamapuloteni ndikuwunika mitundu yomwe ili yoyenera kwambiri pamayendedwe a NaV1.7, NaV1.8, ndi NaV1.9 neural. Ndi AlphaFold, ofufuza amatha kuyesa okha mapuloteni opangidwa ndi Rosetta.
Atangozindikira mapuloteni ochepa odalirika, adapanga ma antibodies omwe amatha kuyesedwa pa minofu ya neural yomwe idapangidwa mu labu. Mayesero a anthu adzatenga zaka zambiri.
Koma ofufuza akusangalala ndi kuthekera kwa njira yatsopanoyi. Non-steroidal anti-inflammatory drugs (NSAIDs), monga ibuprofen ndi acetaminophen, ayenera kumwedwa kangapo patsiku kuti athetse ululu. Opioid painkillers nthawi zambiri amatengedwa tsiku ndi tsiku ndipo amakhala pachiwopsezo cha kuzolowera.
Komabe, ma antibodies a monoclonal amatha kuzungulira m'magazi kupitilira mwezi umodzi asanaphwanyidwe ndi thupi. Ofufuzawo ankayembekezera kuti odwala azidzipatsa okha mankhwala a analgesic monoclonal antibody kamodzi pamwezi.
"Kwa odwala omwe ali ndi ululu wosaneneka, izi ndi zomwe mukufuna," adatero Yarov-Yarovoy. Amamva ululu osati kwa masiku, koma kwa milungu ndi miyezi. Zikuyembekezeka kuti ma antibodies ozungulira azitha kupereka mpumulo wa ululu womwe umatenga milungu ingapo. ”
Mamembala ena agululi ndi Bruno Correia wa EPFL, Steven Waxman wa Yale, EicOsis' William Schmidt ndi Heike Wolf, Bruce Hammock, Teanne Griffith, Karen Wagner, John T. Sack, David J. Copenhaver, Scott Fishman, Daniel J. Tancredi, Hai Nguyen, Phuong Tran Nguyen, Diego Lopez Mateos, ndi Robert Stewart wa UC Davis.
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Nthawi yotumiza: Sep-29-2022